BS3 cross-linking of NAc from FR and AL rats revealed differential distribution of AMPARs in surface (S) and intracellular (I) compartments. A and C: Quantification of GluA1 (A) showed increased surface (S) and total (S+I) expression with a concomitant increase in surface/intracellular (S/I) ratios. No significant change in intracellular (I) pools was observed in FR rats when compared to AL control. Band densities are normalized to α-tubulin and expressed as percentage of AL control. Evaluation of GluA2 (C) revealed no change in surface (S), intracellular (I), surface/intracellular (S/I) ratio, or total (S+I). B and D: Shown are representative immunoblots of BS3 cross-linked samples. Data obtained from individual sujects are expressed in comparison to the normalized control and displayed with mean ± s.e.m., n=10 per group, *p<.05.