Table 2:

Long-term outpatient cardiovascular outcomes following fertility therapy failure

Outcome	Fertility therapy				Relative rate ratio* (95% CI)
	Failure n = 19 093		Success n = 9349
	No.	Rate†	No.	Rate†	Unadjusted	Adjusted‡
Any cardiovascular event	1925	1.08	761	0.91	1.19 (1.11–1.27)	1.21 (1.13–1.30)
Coronary ischemia	392	0.22	175	0.21	1.05 (0.98–1.13)	0.86 (0.80–0.93)
Heart failure	352	0.20	132	0.16	1.25 (1.15–1.37)	2.25 (2.06–2.46)
Venothromboembolism	668	0.37	272	0.32	1.15 (1.07–1.25)	1.08 (1.00–1.17)
Cerebrovascular events	513	0.29	182	0.22	1.32 (1.22–1.44)	1.25 (1.15–1.37)
Ischemic stroke/TIA	468	0.26	156	0.19	1.41 (1.29–1.54)	1.33 (1.22–1.46)
Hemorrhagic stroke	45	0.025	26	0.031	0.81 (0.75–0.89)	0.88 (0.80–0.96)

Note: CI = confidence interval, TIA = transient ischemic attack.

^*Rate ratios represent frequency among women following fertility therapy failure compared with those following successful fertility therapy.

^†Absolute rates denote events per 100 patient-years of follow-up.

^‡Adjusted for age, calendar year, geographic residence, neighbourhood income quintile, prior health care visits, cardiovascular risk factors (e.g., hypertension, diabetes, hypercholesterolemia, smoking and obesity), history of ischemic heart disease, heart failure, atrial fibrillation, asthma, depression, neoplasm, prior live births, miscarriages and stillbirths, and number of fertility cycles.