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. 2004 Dec 15;18(24):3004–3009. doi: 10.1101/gad.1255404

Figure 4.

Figure 4.

Interactions between aak-2 and insulin-like pathway mutants. (A) Effect of aak-2(ok524) on the lifespans of daf-2 and daf-16 mutants. For statistical data see Supplementary Table 1. (B) Role of aak-2 on dauer formation. ★P < 0.0001 compared with daf-2(e1368) (ANOVA). Bottom panels show that wild-type animals and aak-2(ok524) mutants do not form dauers at the temperatures tested. aak-2(RNAi) also suppresses the dauer-constitutive and lifespan extension phenotypes of daf-2(e1368) mutants (data not shown). (C) Model. AAK-2 regulates lifespan in response to changes in the AMP:ATP ratio and insulin-like signals.