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. 2017 Jan 20;8(4):242–254. doi: 10.1007/s13238-017-0369-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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ILC1-specific transcription factors. ILC1 is a newly confirmed group 1 ILC population that is distinct from cNK cells. The special functions of ILC1s and underlying regulatory mechanism still need further investigation. T-bet is the master transcriptional regulator of ILC1 cells and regulates the production of ILC1 effector cytokines IFNγ and TNFα. Runx3 and Cbfβ are also required for the maintenance of mature ILC1s, mainly through regulating the expression of anti-apoptotic proteins, such as Bcl-2