Figure 3.
Drug cocktails protect liver from acute injuries. (A and B) Drug cocktails protect liver from acute injury induced by partial hepatectomy (PHx). (A) Representative images of Ki-67 positive cells (red) at 48 h after PHx are shown in the left panels. Nuclei were stained with DAPI. Right panels show quantification of Ki-67 positive (Ki-67+) cells. HPF, high-power fields. (B) Assessment of liver regeneration treated with drug cocktails after PHx by measuring ratio between liver weight and body weight. (C–E) Drug cocktails protect liver from acute injury induced by CCl4 treatment. (C and D) Serum alanine transaminase (ALT) and aspartate transaminase (AST) activity were analyzed 24 h after CCl4 treatment. (E) Representative images of the liver histopathological changes are shown in the left panels and quantification of histopathological grading is shown in the right panel. All data are presented as mean ± SD. * P < 0.05 vs. control