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. 2017 Mar 21;8:120. doi: 10.3389/fphar.2017.00120

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Copyright © 2017 Yao, Sun, Song, Qi, Tao, Xu, Yin, Han, Xu, Li, Sun and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dioscin adjusts TLR4/MyD88 signal in vivo. (A) Effect of dioscin on the protein levels of TLR4 and MyD88 in mice and rats. (B) Effect of dioscin on the expression levels of TLR4 and MyD88 based on immunofluorescence assay in mice and rats (200 × original magnification). (C) Effect of dioscin on the expression levels of TRAF6, TKB1, TRAF3, p-PI3K, p-Akt, p-IκBα, and p-NF-κB in mice and rats. (D) Effect of dioscin on the mRNA levels of TNF-α, IL-1β, and IL-6 in mice and rats. Values are expressed as the mean ± SEM (n = 3). ^##p < 0.01 compared with control group; *p < 0.05 and **p < 0.01 compared with model group.