Table 1.
Contact map for the ammine ligands (N1–N6) of the iridium(III) hexammine (IRI A303–A309) in the crystal structure of the AdoCbl riboswitch (S. thermophilum) (Peselis and Serganov, 2012).
| NH3 | IRI (A303) | IRI (A304) | IRI (A305) | IRI (A306) | IRI (A307) | IRI (A308) | IRI (A309) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N1 | OP1 | O6 | |||||||||||||||||||
| N2 | O4 | OP1/O5 | OP1 | OP1 | OP2 | OP2 | OP1 | ||||||||||||||
| N3 | O4 | O4 | N7/OP2 | ||||||||||||||||||
| N4 | OP1 | OP1/O5 | N7/O6 | OP1/O5/OP2 | OP1 | OP1 | OP2 | O6 | O6 | ||||||||||||
| N5 | OP1 | O6 | OP1 | OP2 | |||||||||||||||||
| N6 | OP1/O5 | OP1 | OP2 | OP2 | O6 | ||||||||||||||||
| Nucleo-base | U | U | A | G | G* | C* | U | G | G* | C* | C* | C | A* | G* | G | C | G* | G* | G* | G* | A* |
| 34 | 35 | 38 | 64 | 65 | 67 | 100 | 101 | 65 | 68 | 69 | 72 | 73 | 151 | 103 | 104 | 122 | 123 | 41 | 42 | 157 | |
| Region | J2/3 | L5 | J8/10 | L5 | J5/6; J7/6 | J10/11; J11/10 | J3/4; J6/3 | ||||||||||||||
Conserved nucleotides are marked by an asterisk. The conserved A157 (underlined) was shown to interact with the adenine base of the bound AdoCbl.