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. 2017 Mar 21;8:141. doi: 10.3389/fphar.2017.00141

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Copyright © 2017 Leo, Fernando, Tran, Ng, Marshall and Parry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration-response curve to (A) GTN and (B) sensitivity to GTN in endothelium-intact aorta from control, GTN+placebo or GTN+serelaxin rats for 3 days. (C) Aortic superoxide production measured by lucigenin-enhanced chemiluminescence assay from control, GTN+placebo or GTN+serelaxin rats for 3 days. Values are expressed as mean ± SEM, n = 8–11 per group. ^∗P < 0.05, significantly different to control, #P < 0.05, significantly different to GTN+placebo (one-way ANOVA, Tukey’s test). Maximum relaxation (Rmax) values are shown in Table 2.