Table 2.
A comparison of sensitivity (pEC50) and maximum relaxation (Rmax) to GTN, DEA/NO and ACh in endothelium-intact aorta isolated from control, GTN+placebo and GTN+serelaxin treated rats.
| Control |
GTN+placebo |
GTN+serelaxin |
||||
|---|---|---|---|---|---|---|
| Vasodilators | pEC50 | Rmax (%) | pEC50 | Rmax (%) | pEC50 | Rmax (%) |
| GTN | 7.04 ± 0.04 | 94 ± 2 | 6.55 ± 0.05* | 86 ± 3* | 6.96 ± 0.04ˆ# | 94 ± 1ˆ# |
| DEA/NO | 6.81 ± 0.05 | 100 ± 1 | 6.84 ± 0.05 | 101 ± 1 | 6.92 ± 0.06 | 101 ± 1 |
| ACh | 6.18 ± 0.04 | 90 ± 4 | 6.28 ± 0.04 | 88 ± 2 | 6.18 ± 0.03 | 95 ± 4 |
n = 6–11. Results are shown as mean ± SEM. ∗P < 0.05 versus control, #P < 0.05 versus GTN+placebo, one-way ANOVA with Tukey’s post hoc analysis.