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. 2017 Mar 21;10:66. doi: 10.3389/fnmol.2017.00066

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Copyright © 2017 Hou, Wang, Liu, Wang and Long.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of the role of neurodegenerative disease related proteins in SNARE-mediated membrane fusion. In SNARE-mediated membrane fusion, α-syn monomer interacting with synaptobrevin-2, and α-syn oligomers inhibits vesicle docking through interaction with synaptobrevin-2 and negatively charged phospholipids. CSPα form a complex with Hsc70 and SGT protein, and the complex binds to monomeric SNAP-25 to prevent its polymerization, enabling SNARE complex formation. Aβ oligomers impair SNARE complex formation through interaction with syntaxin 1a.