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. 2017 Mar 21;11:79. doi: 10.3389/fncel.2017.00079

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Copyright © 2017 Yao, Wang, Lin, Wu, Zhu, Wang, Shen, Xi, Qi, Jiang, Lü and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transplantation of platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) improves locomotor recovery after spinal cord injury (SCI). (A) Rats that received PDGF-AA-overexpressing OPC transplantation showed greater improvement in locomotor Basso, Bresnahan and Beattie (BBB) score at 3 weeks as compared to controls (n = 15). (B) The PDGF-AA-overexpressing OPC transplantation group had fewer footfall errors in the grid-walk analysis than control animals 6 weeks post-transplantation. Data represent mean ± SD (n = 15). *P < 0.05, **P < 0.01.