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. 2017 Mar 21;11:79. doi: 10.3389/fncel.2017.00079

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Copyright © 2017 Yao, Wang, Lin, Wu, Zhu, Wang, Shen, Xi, Qi, Jiang, Lü and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival of OPCs in the injured spinal cord after transplantation, as determined by activated caspase-3 staining. (A–F) Representative photomicrographs showing caspase-3+ cells (red) co-localized with green fluorescent protein (GFP+) OPCs (green) in the spinal cord of rats that received transplantation of OPCs with or without PDGF-AA overexpression at 1, 2, or 4 weeks. (G) Quantitative analysis of activated caspase-3+ cells. There were fewer caspase-3+ GFP+ cells in the PDGF-AA-overexpressing OPC transplantation group than in the OPC transplantation groups. Data represent mean ± SD (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001. Scale bar = 25 μm.