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. 2017 Mar 21;8:139. doi: 10.3389/fphys.2017.00139

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Copyright © 2017 Chen, Zheng, Feng, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of western diet (WD) and 3,3-Dimethyl-1-butanol (DMB, an inhibitor of trimethylamine formation) on expression of inflammatory cytokines in the hearts. Compared with mice fed a normal diet (ND), mice fed a WD for 8 weeks exhibited increased protein levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-α (B) and interleukin (IL)-1β (C), and decreased protein levels of anti-inflammatory cytokine IL-10 (D), all of which were prevented by DMB treatment. (A) Representative Western blots from each group. Data are presented as mean ± SE (n = 10 for each group). ^*P < 0.05 vs. ND or ND+DMB; ^†P < 0.05, WD+DMB vs. WD.