Table 1. Clinical data on 10 cases of Dent disease.
Patient | Age of onset | Age at diagnosis | Nephrocalcinosis | Renal function | Renal biopsy | Drugs used | Other |
---|---|---|---|---|---|---|---|
No.1 | 5.7 y | 9.8 y | Y | normal | FSGS | Pre, CsA, CTX | N |
No.2 | 4.7 y | 5.8 y | N | normal | MCD | Pre, CTX, Tac | N |
No.3 | 4.8 y | 5.2 y | N | normal | N | Pre, CsA | N |
No.4 | 3.2 y | 4.5 y | N | normal | MsPGN | Pre, CsA, TWP | growth deficiency |
No.5 | 3.2 y | 5.7 y | Y | normal | N | Pre, Tac, MMF | N |
No.6* | 4.1 y | 5.8 y | N | normal | FSGS | Pre, CTX, CsA | rickets |
No.7* | 3.5 y | 3.5 y | N | normal | N | N | N |
No.8 | 1.2 y | 1.5 y | N | normal | N | N | N |
No.9 | 3.8 y | 5.1 y | N | normal | N | Pre, CTX, MMF | growth deficiency |
No.10 | 3.4 y | 5.2 y | N | normal | MCD | Pre, CTX, CsA | congenital cataract and growth deficiency |
Patients 6 and 7 are brothers; N: no; Y: yes; CsA: Cyclosporin A; CTX: Cyclophosphamide; FSGS: Focal segmental glomerulosclerosis; MCD: Minimal change disease; MMF: Mycophenolic acid; MsPGN: Mesangial proliferative glomerulonephritis; Pre: Prednisone; Tac: Tacrolimus; TWP: Tripterygium Glycosides.