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. 2016 Dec 22;66(4):427–440. doi: 10.1007/s00262-016-1945-z

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Levels of serum IFN-γ, IL-12, IL-10 and IL-4 (pg/ml) at baseline, during and after BCG therapy. Patients were stratified by treatment outcome (BCG response vs. BCG failure). Data represent mean ± 95% confidence interval (CI); *p < 0.05; **p < 0.01; ***p < 0.001; overall p value for changes over time points by Skillings–Mack test; p value from a mixed model analysis for repeated measures between responders and non-responders; Mann–Whitney U tests for single time point comparisons between responders and non-responders. IL interleukin