Table 1.

Summary of phenotypic information for genes identified in each cluster

Cell/tissue type	Description	Cluster	No. Genes	No. Genes with KO mouse models	Top phenotype (p value)	No. Genes with human diseases
Nervous system	General	5	144	72	Abnormal synaptic transmission (3.53 × 10−26)	28
		30	67	37	Abnormal nervous system physiology (1.20 × 10−17)	10
		53	19	7	Abnormal behavioural response to alcohol (3.85 × 10−5)	8
		60	21	11	Abnormal neuron physiology (0.001046)	3
		73	17	6	Abnormal CNS synaptic transmission (1.61 × 10−9)	0
		77	19	6		3
	Variable	59	26	12	Abnormal nervous system physiology (3.1 × 10−6)	1
		89	18	6	Increased circulating gastrin level (4.51 × 10−5)	0
		99	13	8		3
Neurons	Isolated neurons and lung	48	31	19	Abnormal vascular development (2.30 × 10−25)	7
	Isolated neurons	45	37	23	Increased systemic arterial blood pressure (2.28 × 10−6)	8
Glia	Astrocytes	6	132	70	Nervous system phenotype (2.11 × 10−7)	24
	Oligodendrocytes	35	50	26	Abnormal myelination (9.54 × 10−9)	3
	Microglia	85	21	10	Abnormal immune system physiology (6.34 × 10−14)	7
Nervous system regions	DRG	27	60	31	Abnormal touch/nociception (7.98 × 10−21)	13
		66	19	5		2
		88	12	3		0
	Cerebellum	37	45	26	Nervous system phenotype (8.0 × 10−10)	6
		56	18	6	Abnormal CNS synaptic transmission (1.96 × 10−8)	4
	Nucleus accumbens	42	39	19	Abnormal behaviour (1.70 × 10−12)	5
		96	14	7	Decreased susceptibility to diet-induced obesity (0.000936)	4
	Spinal cord	90	13	6		4
	Olfactory bulb	82	18	7	Abnormal facial nerve morphology (0.001383)	0
Myelin	Synthesis	91	8	4	Impaired coordination (0.000315)	1
Other	Testis	1	1627	288	Abnormal male reproductive system physiology (2.16 × 10−125)	103
	Mitochondria	14	87	10	Decreased embryo size (0.000874156)	32