The blood lipid-lowering effects of OLL2712 cells on KKAy mice were affected by their culture phases. The 8-h (+) or 14-h (+) OLL2712 cells were administered to KKAy mice for 3 weeks. After 4 h of fasting, the serum concentrations of triglycerides, free fatty acids, and total cholesterols were measured. The results are presented as means ± SE (n = 6). Significant differences compared with the control group were determined by Dunnett's test (*, P < 0.05; **, P < 0.01). Data are representative of 2 independent experiments.