Table 4.
Interaction and Sex-Stratified Results Published Top COPD GWAS Affection Alleles
| |
|
|
|
All Subjects |
Males |
Females |
|---|---|---|---|---|---|---|
| Chr | Gene | SNP | Published P value | Interaction P Value | P Value | P Value |
| 15 | CHRNA3 | rs4416442 | 1.12 × 10−14 | 0.08 | 1.68 × 10−5 | 1.78 × 10−9 |
| 4 | FAM13A | rs12914385 | 6.38 × 10−14 | 0.25 | 1.70 × 10−5 | 3.30 × 10−5 |
| 4 | HHIP | rs13141641 | 1.57 × 10−12 | 0.59 | 1.70 × 10−5 | 3.72 × 10−6 |
| 14 | RIN3 | rs754388 | 5.25 × 10−9 | 0.03 | 1.04 × 10−2 | 1.84 × 10−7 |
| 11 | MMP3/12 | rs626750 | 5.35 × 10−9 | 0.38 | 7.81 × 10−5 | 1.82 × 10−2 |
| 1 | TGFB2 | rs4846480 | 1.25 × 10−7 | 0.86 | 2.48 × 10−3 | 1.54 × 10−3 |
Definition of abbreviations: COPD, chronic obstructive pulmonary disease; Chr, chromosome; GWAS, genome-wide association; SNP, single-nucleotide polymorphism.
Published P values are results from prior COPDGene affection status analysis (19); interaction P values are results from SNP × sex interaction test for the outcome, COPD case–control status, including COPDGene non-Hispanic white and African American, ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points), and GenKOLS (Genetics of Chronic Obstructive Lung Disease) subjects. Male and female P values indicate results from male- and female-stratified meta-analysis of COPDGene non-Hispanic white, African American, ECLIPSE, and GenKOLS subjects. Results are from stratified logistic regression, adjusting for age, pack-years, and principal components.