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. 2017 Mar;56(3):405–408. doi: 10.1165/rcmb.2016-0258LE

Figure 2.

Figure 2.

SOD1G93A mice have evidence of pulmonary restriction as early as 13 weeks of age. Using forced oscillation, measurements of pulmonary mechanics are shown in (A) lung capacity (A), (B) overall respiratory resistance (Rrs), (C) tissue damping (G), and (D) compliance (Crs) in SOD1G93A (gray bars, n = 7 at 13 wk, n = 8 at 18 wk, and n = 6 at end stage) mice as compared with NTG (black bars, n = 6 at 13 wk, n = 8 at 18 wk, and n = 7 at time point of littermate end-stage SOD1G93A) littermates. Pressure–volume measurements also reveal age-dependent decreases in lung volumes (E and F) in SOD1G93A mice (gray lines, n = 8 for E; n = 6 for F) as compared with NTG (black lines, n = 8 for E; n = 7 for F) littermates. (A–D) *P < 0.05; **P < 0.01 (two-way ANOVA). (E and F) *P < 0.05 compared with NTG lung volume at the same pressure; **P < 0.001 compared with NTG lung volume at the same pressure (two-way repeated measures ANOVA).