Table 2. Genes identified for LMI by gene-based association test.
Gene | Chr | Start | Stop | No. SNPs | Discovery |
Replication |
Combined | ||
---|---|---|---|---|---|---|---|---|---|
z | p | z | p | p | |||||
UQCR | 19 | 1548170 | 1556431 | 30 | 2.36 | 6.10 × 10−5 | 0.30 | 2.21 × 10−3 | 2.26 × 10−6 |
TCF3 | 19 | 1560294 | 1601277 | 51 | 1.84 | 1.65 × 10−4 | 0.41 | 1.84 × 10−3 | 4.86 × 10−6 |
MBD3 | 19 | 1527677 | 1543652 | 47 | 1.82 | 1.10 × 10−4 | 0.18 | 6.95 × 10−3 | 1.15 × 10−5 |
Notes: Z-score was the average z-scores over all included SNPs. z-score at each SNP was referred to the increasing-allele in the discovery sample whose z-score was positive by definition. Genome-wide significance (GWS) level significant result was marked in bold.