Table 5. Brain expression modules significantly dysregulated both in HD brain and HD blood.
| Module number | Brain Region | Module name | Number of genes | p (combined) | p (TRACK) | p (Leiden) | cor (HD brain) | p (HD brain) | Description |
|---|---|---|---|---|---|---|---|---|---|
| 69 | FC_BA4 | FC4pos1 | 712 | 3.77E-08 | 3.05E-05 | 1.32E-03 | 0.610 | 3.77E-03 | Inflammatory response |
| 48 | CN | CNpos2 | 1785 | 2.03E-07 | 3.85E-03 | 6.33E-03 | 0.724 | 2.21E-11 | Lipid metabolism/regulation of transcription |
| 64 | CN | CNpos6 | 114 | 3.13E-04 | 1.18E-02 | 3.80E-02 | 0.463 | 2.28E-04 | Inflammatory response |
| 66 | CN | CNneg1 | 2644 | 2.71E-07 | 1.51E-04 | 2.13E-02 | −0.800 | 6.03E-15 | Synapse |
All modules in this table are significantly dysregulated after correction for multiple testing (q < 0.05) in the combined blood sample, and are nominally significantly dysregulated (p < 0.05) in both Track-HD and Leiden datasets separately. Cor(HD brain) – the correlation between module eigengene and HD status observed by Neueder and Bates30 in brain expression data, with a positive correlation corresponding to upregulation in HD. p(HD brain) is the p-value for that correlation (corrected for multiple testing of modules).