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. 2017 Mar 21;7:44912. doi: 10.1038/srep44912

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(a) 2D plot of VCP/p97 interactions with NMS-873 inhibitor and (b) its docked pose into the predicted binding site. (c) 2D plot of interactions between UPCDC30245 inhibitor and VCP/p97 and (d) the docked pose of NMS-873 and the experimental pose UPCDC30245 inhibitor (magenta) into the VCP/p97 binding site. Each monomer of VCP/p97 is in color green and red, respectively. The surface of Lys 614, Lys 615 and Asn 616, critical residues for the allosteric binding, is indicated in color magenta, cyan and yellow, respectively.