Table 3. IC50 values (μM) of cell-based assays for the compounds predicted by docking and CMAP analysis.
Compound | UbG76V-GFP IC50 | ODD-Luc IC50 |
---|---|---|
MG132a | 1.2 | 4.4 |
NMS-873a | 1.4 | >40 |
Niclosamide | >40 | >40 |
Ivermectin | 9.7 | >40 |
Clotrimazole | 1.4 | >40 |
Saquinavir | 10.7 | 20.8 |
Astemizole | 13.1 | 16.9 |
Iloprost | >40 | >40 |
Ebastine | 12.0 | 12.6 |
aPositive control.