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. 2017 Mar 21;7:44912. doi: 10.1038/srep44912

Table 4. IC50 values (μM) for the selected compounds against WT, E305Q, or E578Q VCP/p97 ATPase activities at 200 μM ATP obtained with 8-dose titration.

Compound WT D2- Walker B mutant D1- Walker B mutant
E578Q E305Q
DMSO >30 >30 >30
DBeQa 3 11.0 5.5
NMS-873a 0.038 1.3 0.038
Ebastine 25 16.6 >30
Ivermectin >30 >30 >30
Clotrimazol 12 8.2 8.0
Saquinavir >30 >30 >30
Astemizole 25 >30 >30

aPositive control.