Fig. 1.

Spinal cord injury (SCI) does not change membrane responses to specific KCNQ channel blocker, XE991. (A) Representative traces (recorded from naïve dorsal root ganglion [DRG] neuron) and summary data showing that bath application of XE991 (10 μM) depolarized and induced repetitive firing in small DRG neurons. No significant differences were found in the depolarization of DRG neurons dissociated from naïve, sham or SCI rats. (B) XE991-sensitive currents are unchanged after SCI. Cells were held at −20 mV and hyperpolarized to −60 mV for 500 ms. KCNQ currents were obtained by measuring the difference in amplitude at the beginning of the hyperpolarizing pulse in the absence (black) and presence (red) of XE991 (10 μM).