Table 1. Clinicopathological factors and association with TILs in ESCC.
No. | sTIL (>10%) | P value | iTIL (>10%) | P value | |||
---|---|---|---|---|---|---|---|
Low | High | Low | High | ||||
Sex | 0.634 | 0.761 | |||||
Female | 38 | 23 | 15 | 23 | 15 | ||
Male | 197 | 111 | 86 | 114 | 83 | ||
Age | 0.472 | 0.904 | |||||
<60 | 97 | 58 | 39 | 57 | 40 | ||
≥60 | 139 | 77 | 62 | 80 | 58 | ||
Differentiation | 0.377 | 0.023 | |||||
well | 4 | 3 | 1 | 3 | 1 | ||
moderate | 133 | 71 | 62 | 87 | 46 | ||
poor | 98 | 60 | 38 | 47 | 51 | ||
Vessel invasion | 0.798 | 0.545 | |||||
No | 189 | 107 | 82 | 112 | 77 | ||
Yes | 46 | 27 | 19 | 25 | 21 | ||
Nerve invasion | 0.498 | 0.518 | |||||
No | 166 | 97 | 69 | 99 | 67 | ||
Yes | 69 | 37 | 32 | 38 | 31 | ||
Lymph node metastasis | 0.475 | 0.383 | |||||
No | 111 | 66 | 45 | 68 | 43 | ||
Yes | 124 | 68 | 56 | 69 | 55 | ||
Site | 0.026 | 0.210 | |||||
Upper | 12 | 4 | 8 | 4 | 8 | ||
Middle | 112 | 73 | 39 | 67 | 45 | ||
Lower | 102 | 52 | 50 | 59 | 43 | ||
Stage | 0.699 | 0.646 | |||||
I–II | 136 | 79 | 57 | 81 | 55 | ||
III–IVa | 99 | 55 | 44 | 56 | 43 | ||
Smoking | 0.624 | 0.570 | |||||
No | 134 | 78 | 56 | 80 | 54 | ||
Yes | 100 | 55 | 45 | 56 | 44 |
sTIL, stromal infiltrating lymphocytes; iTIL, intratumoural infiltrating lymphocytes.