Table 2. Univariate and multivariate Cox regression analyses of patient and tumour factors with DFS and OS.
| P value | DFS | P value | OS | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Univariate analysis | ||||
| sTIL (>10%) | 0.083 | 0.743 (0.531–1.040) | 0.037 | 0.697 (0.496–0.979) |
| iTIL (>10%) | 0.508 | 1.119 (0.802–1.561) | 0.616 | 1.090 (0.777–1.530) |
| iTIL (>20%) | 0.050 | 0.508 (0.259–0.999) | 0.042 | 0.477 (0.234–0.974) |
| sCD4 (>10%) | 0.741 | 0.897 (0.472–1.707) | 0.490 | 0.788 (0.401–1.549) |
| sCD8 (>10%) | 0.791 | 0.953 (0.667–1.361) | 0.569 | 0.900 (0.626–1.294) |
| iCD8 (>10%) | 0.706 | 0.929 (0.634–1.361) | 0.585 | 0.896 (0.603–1.330) |
| sFoxp3 (>10%) | 0.641 | 0.717 (0.177–2.900) | 0.604 | 1.447 (0.358–5.854) |
| iFoxp3 (>10%) | 0.478 | 0.603 (0.149–2.437) | 0.239 | 0.307 (0.043–2.194) |
| Sex | 0.991 | 0.999 (0.799–1.249) | 0.901 | 1.015 (0.808–1.274) |
| Age | 0.927 | 0.985 (0.705–1.375) | 0.967 | 0.993 (0.709–1.390) |
| Grade | 0.106 | 1.300 (0.946–1.788) | 0.142 | 1.273 (0.922–1.757) |
| Vessel invasion | 0.002 | 1.793 (1.235–2.605) | <0.001 | 1.996 (1.371–2.906) |
| Nerve invasion | 0.401 | 1.164 (0.817–1.659) | 0.226 | 1.248 (0.872–1.785) |
| Lymph node metastasis | <0.001 | 3.128 (2.178–4.494) | <0.001 | 3.476 (2.404–5.026) |
| Stage | <0.001 | 3.274 (2.330–4.600) | <0.001 | 3.580 (2.536–5.053) |
| Site | 0.042 | 0.758 (0.580–0.990) | 0.066 | 0.775 (0.590–1.017) |
| Smoking | 0.369 | 1.164 (0.836–1.619) | 0.178 | 1.257 (0.901–1.754) |
| Multivariate analysis | ||||
| sTIL (>10%) | 0.019 | 0.664 (0.473–0.934) | 0.005 | 0.608 (0.431–0.857) |
| iTIL (>20%) | 0.095 | 0.561 (0.284–1.106) | 0.087 | 0.534 (0.260–1.095) |
| Vessel invovlement | 0.506 | 1.142 (0.773–1.687) | 0.327 | 1.217 (0.822–1.803) |
| Lymph node metastasis | 0.010 | 1.950 (1.169–3.252) | 0.004 | 2.118 (1.265–3.545) |
| Stage | 0.004 | 2.040 (1.256–3.312) | 0.002 | 2.119 (1.303–3.446) |
DFS, disease free survival. OS, disease specific overall survival. HR, hazard ratio. CI, confidence interval. sTIL, stromal infiltrating lymphocytes. iTIL, intratumoural infiltrating lymphocytes. sCD4, CD4+ stromal infiltrating lymphocytes. sCD8, CD8+ stromal infiltrating lymphocytes. iCD8, CD8+ intratumoural infiltrating lymphocytes. sFoxp3, Foxp3+ stromal infiltrating lymphocytes. iFoxp3, Foxp3+ intratumoural infiltrating lymphocytes.