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. 2017 Mar 15;34(6):1175–1186. doi: 10.1089/neu.2016.4641

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Copyright 2017, Mary Ann Liebert, Inc.

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FIG. 8. — Array assessment of the expression of cell cycle and DNA function genes' messenger RNA (mRNA) transcripts at 72 h post-surgery. Whisker plots illustrate the median (horizontal bar), the 25th to 75th percentile (box) and the minimum to maximum value (whiskers). All values were scaled to set the sham mean equal to 1 (horizontal dotted line). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. CEP290 mRNA expression is altered between groups (analysis of variance [ANOVA: p = 0.0341) but the multiple comparison test failed to differentiate between groups. TAF1D mRNA expression is elevated in sham animals (sham vs. naïve: p ≤ 0.0001), and suppressed in spinal cord injury (SCI) animals (SCI vs. sham: p ≤ 0.0001; SCI vs. naïve: p ≤ 0.001), with a mean fold change vs. sham of 0.5214 (ANOVA: p < 0.0001). IWS1 mRNA expression is elevated in sham animals (sham vs. naïve: p ≤ 0.0001), and less elevated in SCI animals (SCI vs. sham: p ≤ 0.01; SCI vs. naïve: p ≤ 0.0001), with a mean fold change vs. sham of 0.6554 (ANOVA: p < 0.0001).CCNC mRNA expression is suppressed in SCI animals, compared with sham (sham vs. naïve: p ≤ 0.001), with a mean fold change vs. sham of 0.8242 (ANOVA: p = 0.0014). MTRR mRNA expression is elevated in sham animals (sham vs. naïve: p ≤ 0.01), but is not in SCI animals (SCI vs. sham: p ≤ 0.001), with a mean fold change vs. sham of 0.5730 (ANOVA: p = 0.0003). MTRR alt mRNA expression is elevated in sham animals (sham vs. naïve: p ≤ 0.01), but is not in SCI animals (SCI vs. sham: p ≤ 0.01), with a mean fold change vs. sham of 0.6093 (ANOVA: p = 0.0022). ALKBH8 mRNA expression is elevated in sham animals (sham vs. naïve: p ≤ 0.01) but not in SCI animals (SCI vs. sham: p ≤ 0.001), with a mean fold change vs. sham of 0.5452 (ANOVA: p = 0.0002). IFT74 mRNA expression is suppressed in SCI animals (SCI vs. sham: p ≤ 0.05, SCI vs. naïve: p ≤ 0.01), with a mean fold change vs. sham of 0.6086 (ANOVA: p = 0.0009). ZNF519 mRNA expression is suppressed in SCI animals (SCI vs. sham: p ≤ 0.01, SCI vs. naïve: p ≤ 0.01), with a mean fold change vs. sham of 0.5451 (ANOVA: p = 0.0014). HELQ mRNA expression is elevated in SCI animals (SCI vs. naïve: p ≤ 0.05), with a mean fold change vs. naive of 2.169 (ANOVA: p = 0.0182).