Table 1.
Top Ranking Response Genes Up-Regulated in CNS Injury Have HuR Binding Sites in the mRNA
| Gene | Name | Fold increase in SCI1 | Fold increase in TBI2 | Function in CNS injury3 | HuR Binding Sites4 |
|---|---|---|---|---|---|
| IL-1β | Interleukin 1β | 160 | 34 | I, C | 4 |
| LIF | Leukemia inhibitory factor | 32 | 16 | I, C | 20 |
| IL-6 | Interleukin 6 | 168 | 48 | I | 4 |
| TNF-α | Tumor necrosis factor alpha | 23 | 610 | I, C, E | 12 |
| CXCL1 | C-X-C motif chemokine ligand 1 | n.a. | 161 | C | 9 |
| CCL2 | C-C motif ligand 2 | 230 | 144 | C | 4 |
| MMP12 | Matrix metalloproteinase-12 | 189 | 154 | I, E | 9 |
1
Based on data published elsewhere ranking the relevance of gene responses in spinal cord injury.22,51
2
Based on data published elsewhere investigating mRNA expression in response to traumatic brain injury.23
3
I, inflammation; C, chemotaxis; E, edema.
4
Binding sites located in 3′ untranslated region of mRNA based on consensus sequences identified previously.24,25
CNS, central nervous system; HuR, human antigen R; mRNA, messenger RNA; SCI, spinal cord injury; TBI, traumatic brain injury.