Skip to main content
. Author manuscript; available in PMC: 2017 Dec 7.
Published in final edited form as: J Am Chem Soc. 2016 Nov 28;138(48):15563–15570. doi: 10.1021/jacs.6b10354

Figure 5.

Figure 5

(A) Structures of the analogues 15e–15i, 19, and 15j. (B) DNA alkylation assay employing linearized pBR322 DNA and the unsaturated lactam 19 or the unsaturated imine 15j. Conditions: Linearized pBR322 DNA (20 μM in base pairs), 19 (500, 100, 10, or 1 μM) or 15j (500, 100, 10, or 1 μM), 37 °C, 15 h.