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. 2016 Dec 20;158(4):660–668. doi: 10.1097/j.pain.0000000000000810

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Copyright © 2016 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Plasma and brain exposure of anti-transferrin variants in a mouse PK assay. (A) Plasma PK of anti-TfR variants and isotype control (NIP228) over a 2-week period. N = 6 per group (B) Brain exposure as a measure of % injected dose per gram of brain. (C) Spinal cord exposure as a measure of % injected dose per gram of spinal cord. PK, pharmokinetic; TfR, transferrin receptor.