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Dose response of 8D3130-IL-1RA fusions on the reversal of partial nerve ligation–induced mechanical hyperalgesia. N = 8 to 9 per group. **P < 0.01; ***P < 0.001 Op + NIP228 vs Op + 8D3130-IL-1RA (100 mg/kg); +++P < 0.001 Op + NIP228 vs Op + 8D3130-IL-1RA (50 mg/kg); ###P < 0.001 Op + NIP228 vs Op + 8D3130-IL-1RA (20 mg/kg); ns not significant (P > 0.5). s.c, subcutaneous.
