Table 2.
Binary and multiple logistic regression model showing determinants of non-adherence to antiretroviral therapy, among adults on ART Aksum town, northern Ethiopia 2015
| Explanatory variables | Adherence status to ART | COR (95% CI) | AOR (95% CI) | |
|---|---|---|---|---|
| Non-adherent number (%) | Adherent number (%) | |||
| Sex | ||||
| Male | 69 (50.4) | 170 (62) | 1 | 1 |
| Female | 68 (49.6) | 104 (38) | 1.6 (1.1–2.4) | 1.4 (0.8–2.4) |
| Age | ||||
| 18–29 | 23 (16.8) | 54 (19.7) | 1 | 1 |
| 30–39 | 60 (43.8) | 127 (46.4) | 1.1 (0.6–2.0) | 1.1 (0.5–2.4) |
| 40–49 | 35 (25.5) | 74 (27) | 1.1 (0.6–2.1) | 0.7 (0.3–1.7) |
| ≥50 | 19 (13.9) | 19 (6.9) | 2.3 (1.1–5.2) | 1.7 (0.6–5.0) |
| Residence | ||||
| Urban | 114 (83.2) | 253 (92.3) | 1 | 1 |
| Rural | 23 (16.8) | 21 (76.7) | 2.4 (1.3–4.6) | 1.4 (0.5–4.0 |
| Occupation | ||||
| No occupation | 21 (15.3) | 42 (15.3) | 1 | 1 |
| Employed | 25 (18.3) | 52 (19) | 0.9 (0.5–2) | 1.4 (0.5–4.2) |
| Business | 40 (29.2) | 96 (35) | 0.8 (0.4–1.6) | 1.8 (0.7–4.0) |
| Farmer | 14 (10.2) | 10 (3.7) | 2.8 (1.1–7.4) | 2.3 (0.5–10.3) |
| Daily laborer | 37 (27) | 74 (27) | 1 (0.5–1.9) | 1.9 (0.8–4.7) |
| Duration on ART (months) | ||||
| 6–12 | 7 (5.1) | 38 (13.9) | 1 | 1 |
| 13–24 | 14 (10.2) | 38 (13.9) | 2.0 (0.7–5.5) | 2 (0.5–8.8) |
| ≥25 | 116 (84.7) | 198 (72.2) | 3.2 (1.4 7.4) | 7 (2.2,22.6)** |
| ART adverse effect | ||||
| Yes | 26 (19) | 3 (1.1) | 21.2 (6.3–71.3) | 6.9 (1.4,32.9)** |
| No | 111 (81) | 271 (98.9) | 1 | 1 |
| Substance use | ||||
| Yes | 21 (15.3) | 5 (1.8) | 9.7 (3.6–26.5) | 5.3 (1.4–20.0)* |
| No | 116 (84.7) | 269 (98.2) | 1 | 1 |
| Live with | ||||
| Alone | 33 (24.1) | 83 (30.3) | 1 | 1 |
| Parents | 18 (13.1) | 21 (7.7) | 2.2 (1.02–4.6) | 3.4 (1.2–10.3)* |
| Family | 86 (62.8) | 170 (62) | 1.3 (0.8–2.1) | 1.5 (0.8–2.8) |
| Depression status | ||||
| Depressed | 41 (29.9) | 19 (6.9) | 5.7 (3.2–10.4) | 3.3 (1.4–7.5)* |
| Not depressed | 96 (70.1) | 255 (93.1) | 1 | 1 |
| CD4 cell count (cells/mm3) | ||||
| <350 | 58 (42.3) | 45 (16.4) | 3.7 (2.4–6.0) | 3.2 (1.8–5.8)* |
| ≥350 | 79 (57.7) | 229 (83.6) | 1 | 1 |
| Dietary diversity | ||||
| Low | 57 (41.6) | 43 (15.7) | 3.8 (2.4–6.1) | 2 (1.1–3.7)* |
| Medium and above | 80 (58.4) | 231 (84.3) | 1 | 1 |
| Daily eating pattern | ||||
| ≤2 meals | 69 (50.4) | 103 (37.6) | 1.7 (1.1–2.6) | 1.01 (0.6–1.8) |
| ≥3 meals | 68 (49.6) | 171 (62.4) | 1 | 1 |
| Opportunistic infection | ||||
| Yes | 28 (20.4) | 5 (1.8) | 13.8 (5.2–36.7) | 3.6 (1–13.1) |
| No | 109 (79.6) | 269 (98.2) | 1 | 1 |
| Reminder use | ||||
| Yes | 127 (92.7) | 268 (97.8) | 0.3 (0.1–0.8) | 0.5 (0.–2.0) |
| No | 10 (7.3) | 6 (2.2) | 1 | 1 |
| Stigma | ||||
| Yes | 17 (12.4) | 10 (3.6) | 3.7 (1.7–8.4) | 2.8 (0.9–8.5) |
| No | 120 (87.6) | 264 (96.4) | 1 | 1 |
| WHO stage | ||||
| Stage I | 16 (11.7) | 68 (24.8) | 1 | 1 |
| Stage II and above | 121 (88.3) | 206 (75.2) | 2.5 (1.4–4.5) | 1.6 (0.8–3.5) |
| BMI | ||||
| Under weight | 38 (27.7) | 41 (15) | 1 | 1 |
| Normal | 97 (70.8) | 224 (81.7) | 0.5 (0.3–0.8) | 0.7 (0.3–1.3) |
| Over weight | 2 (1.5) | 9 (3.3) | 0.2 (0.1–1.2) | 0.4 (0.01–3.0) |
| Treatment other than ART | ||||
| Yes | 41 (29.9) | 40 (14.6) | 2.5 (1.5–4.1) | 1.4 (0.7–3.0) |
| No | 96 (70.1) | 234 (85.4) | 1 | 1 |
* p < 0.05
** p < 0.001