Table 1.
Association of HER2 expression and clinicopathological parameters
| Clinicopathological parameters | Number of studies | Number of patients | OR (95% CI) | P | Heterogeneity | |
|---|---|---|---|---|---|---|
| I 2 (%) | P value | |||||
| Age (old vs young) | 27 | 12,800 | 0.90(0.74,1.10) | 0.31 | 62.9 | 0.00 |
| Sex (male vs female) | 33 | 15,304 | 1.48(1.34,1.65) | 0.00 | 21.1 | 0.14 |
| Tumor size (large vs small) | 11 | 1614 | 0.83(0.64,1.07) | 0.21 | 13.4 | 0.32 |
| Tumor site (proximal vs distal) | 24 | 12,853 | 1.25(1.07,1.47) | 0.01 | 27.4 | 0.11 |
| Lauren’s classification (intestinal vs diffuse) | 30 | 13,972 | 3.37(2.54,4.47) | 0.00 | 74.2 | 0.00 |
| TNM stage (III+IV vs I+II) | 24 | 12,542 | 1.35(1.10,1.66) | 0.01 | 62.4 | 0.00 |
| Lymph node metastasis(N+ vs N−) | 27 | 14,075 | 1.26(1.14,1.41) | 0.03 | 0.0 | 0.66 |
| Differentiation grade (well vs poor) | 28 | 9086 | 1.79(1.15,2.76) | 0.01 | 86.6 | 0.00 |
| Distant metastasis (M+ vs M−) | 9 | 4427 | 1.91(1.08,3.38) | 0.00 | 54.4 | 0.03 |
| Lymphovascular invasion (yes vs no) | 10 | 3957 | 1.30(0.86,1.95) | 0.22 | 62.5 | 0.00 |
| Neural invasion (yes vs no) | 4 | 1361 | 0.58(0.24,1.37) | 0.21 | 80.1 | 0.00 |
OR odds ratio, CI confidence interval, N node, M metastasis