Fig. 7. (a) Representative curves of ThT fluorescence assays over time showing Aβ1–42 (10 μM) aggregation in the absence (purple curve) and in the presence of compounds G1b (red curves) and G2b (blue curves) at compound/Aβ1–42 ratios of 10/1 and 1/1. The control curves are represented in dotted lines (G1b in red, G2b in blue and grey for buffer). Fibril formation of Aβ1–42 visualized by TEM: negatively stained images recorded after 42 h of incubation of Aβ1–42 (10 μM in 10 mM Tris·HCl, 100 mM NaCl at pH = 7.4) alone (b) or in the presence of 10 μM of G1b (c) or G2b (d). Scale bars represent 500 nm.
