Table 1. Effects of compounds G1–2 on Aβ1–42 fibrillization assessed by ThT-fluorescence spectroscopy at 10/1 and 1/1 compound/Aβ ratios (the concentration of Aβ1–42 is 10 μM) and compared to the values obtained for Aβ1–42 alone (t 1/2 and F) a .
| Compounds (Compound/Aβ ratio) | t 1/2 extension b | Change of fluorescence intensity at the plateau c (%) |
| G1a (10/1) | NA | –97 ± 1% |
| G1a (1/1) | 2.06 ± 0.12 | –71 ± 2% |
| G2a (10/1) | Sat d | Sat d |
| G2a (1/1) | 1.76 ± 0.11 | –41 ± 7% |
| G1b (10/1) | NA | –97 ± 1% |
| G1b (1/1) | NA | –90 ± 2% |
| G2b (10/1) | NA | –95 ± 1% |
| G2b (1/1) | >3.56 ± 0.12 | –73 ± 3% |
a NA = no aggregation, parameters are expressed as mean ± SE, n = 3–6.
b See ESI for the calculation of the t 1/2 extension. A compound displaying a t 1/2 increase >1 is a delayer of aggregation.
c See ESI for the calculation of the change of fluorescence intensity at the plateau.
d Sat means that a saturation of the fluorescence signal is observed because G2a self-aggregates at 100 μM.