Table 1.
Baseline patient characteristics and CT-proET-1 serum measurements at ICU admission
| Parameter | All patients | Sepsis | Non-sepsis | p a |
|---|---|---|---|---|
| Number | 217 | 144 | 73 | |
| Sex (male/female) | 132/85 | 84/60 | 48/25 | n.s. |
| Age median, (range) [years] | 64 (18–90) | 65 (20–90) | 61 (18–85) | n.s. |
| APACHE-II score, median (range) | 18 (2–43) | 19 (4–43) | 14 (2–33) | <0.001 |
| SOFA score, median (range) | 9 (0–17) | 9 (2–17) | 7 (0–17) | 0.003 |
| SAPS 2 score, median (range) | 41 (0–73) | 40 (0–73) | 41 (0–73) | 0.193 |
| Mechanical ventilation, n (%) | 144 (69) | 98 (63) | 46 (63) | n.s. |
| Ventilation time, median (range) [h] | 117 (0–3828) | 125.5 (0–2966) | 66 (0–2828) | n.s. |
| Vasopressor demand, n (%) | 132 (60.8) | 99 (68.8) | 33 (45.2) | <0.001 |
| ICU days, median (range) | 7 (1–137) | 8.5 (1–137) | 6 (1–45) | 0.004 |
| 30-day mortality, n (%) | 41 (18.9) | 34 (23.6) | 7 (9.6) | 0.016 |
| Overall mortality, n (%) | 86 (41.7) | 64 (46.7) | 22 (31.9) | 0.42 |
| CT-proET-1, median (range) [pmol/L] | 43.8 (3–503.6) | 82.1 (3–503.6) | 40.9 (3–372.9) | <0.001 |
| Leucocytes, median (range) [per nL] | 12.9 (0.5–208) | 13.8 (0.5–208) | 12.5 (1.8–29.6) | 0.041 |
| CRP, median (range) [mg/L] | 98 (5–230) | 160.5 (5–230) | 17 (5–230) | <0.001 |
| Cystatin C, median (range) [mg/L] | 1.48 (0.39–8.38) | 1.69 (0.39–8.38) | 1.04 (0.56–2.29) | <0.001 |
| Bilirubin, median (range) [per mg/dL] | 0.7 (0.2–20.8) | 0.7 (0.2–6.8) | 0.7 (0.2–20.8) | n.s. |
For quantitative variables, median and range (in parenthesis) are given
Abbreviations: CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, APACHE Acute Physiology and Chronic Health Evaluation, SAPS 2 Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, n.s. not significant
aSignificance between sepsis and non-sepsis patients was assessed using the Mann-Whitney U test or chi-squared test