Table 4.

Uni- and multivariate Cox regression analyses for CT-proET-1 levels at ICU admission to predict overall mortality

	Unadjusted HR (95%-CI)	p	Adjusted HR (95%-CI)	p
CT-proET-1 > 74 pmol/L	2.731 (1.535–4.858)	0.001	2.193 (1.209–3.975)	0.01
Creatinine (per mg/dL)	1.034 (0.946–1.129)	0.461	–	n.s.
CRP (per mg/L)	1.002 (0.999–1.006)	0.129	–	n.s.
Bilirubin (per mg/dL)	1.16 (0.935–1.16)	0.176	–	n.s.
Prothrombin time (per %)	0.99 (0.979–1)	0.052	–	n.s.
Lactate (per mmol/L)	1.082 (0.949–1.234)	0.239	–	n.s.
Age (per year)	1.036 (1.014–1.059)	<0.001	1.028 (1.005–1.051)	0.04

Variables with a univariate p < 0.25 were included in the multivariate model

Abbreviations: 95%-CI 95% confidence-interval, CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, n.s. not significant