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. 2017 Mar 21;17:204. doi: 10.1186/s12885-017-3193-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — High dose MK2206 inhibits glioma migration and invasion. a Number of cells invaded through matrigel after 16 h in the presence of 1 μM, 5 μM, or 10 μM MK2206. Columns represent means, ±SD (n = 3), * = p < 0.05. b Percentage of scratch area remaining compared to 0 h. Columns represent means, ±SD (n = 10 replicates), * = p < 0.05. c Area of spheroid outgrowth. Spheroids were treated with 1 μM MK and 4 Gy irradiation and plated in regular culture plates. Data points represent means, ±SD, (n = 8 replicates), * = p < 0.05