Table 1.
Differences in tumor-VM and ECs-dependent angiogenesis and VM inducer and suppressor molecules
| Normal endothelial cells | Vasculogenic mimicry cells |
|---|---|
| Similarities | |
| VE-cadherin positive | |
| E-selectin positive | |
| CD34 positive | |
| Differences | |
| TIE-2 positive | TIE-2 negative |
| VEGFR-1, 2 positive | VEGFR-1, 2 negative |
| P-selectin positive | P-selectin negative |
| VCAM-1/CD106 positive | VCAM-1/CD106 negative |
| CD31/PECAM-1 positive | CD31/PECAM-1 negative *13 (Subpopulations PECAM-1 positive melanoma cells) |
| TIE-1 negative | TIE-1 positive |
| VEGF-C negative | VEGF-C positive |
| Neuropilin 1 negative | Neuropilin 1 positive |
| Endoglin negative | Endoglin positive |
| Tissue factor pathway inhibitor 1 (TFPI1) negative | Tissue factor pathway inhibitor 1 (TFPI1) positive |
| Laminin 5 gamma 2 chain (LAMC2) negative | Laminin 5 gamma 2 chain (LAMC2) positive |
| EphA-2 negative | EphA-2 positive |