Table 2.
Acute coronary syndrome (ACS) in patients with co‐existing cardiovascular disease in critical care blood transfusion threshold trials. Diagnosis made by Investigator (I) or Clinician (C)
| Author, year | Population | Blinded y/n | Diagnosis of ACS | Incidence of new ACS |
|---|---|---|---|---|
| de Almeida, 2015 [27] | Major abdominal cancer surgery | Y (I) | Clinical symptoms suggesting myocardial ischemia with ≥ 1 of the following: increase/decrease in cTnI (≥1 value > 99th centile upper reference limit); EKG changes: new Q waves, ST elevation, new LBBB; Image‐based evidence of new loss of viable myocardium |
R: 0/22 L: 0/12 |
| Hebert, 1999 [9] | General ICU | ? (I) | Unclear | * |
| Holst, 2014 [11] | Septic shock | Y (I) | Symptoms, EKG signs, or elevated biomarker levels resulting in an intervention | R: 6/75 L: 2/66 |
| Walsh, 2013 [14] | Older, mechanically ventilated | N (C) | Troponin rise, new EKG change | R: 1/17 L: 0/15 |
*All complications, including shock, myocardial infarction, unstable angina and cardiac arrest, with the exception of acute pulmonary edema (9 vs. 18%; p < 0.01), were comparable in both groups (p > 0.05). LBBB left bundle branch block, R restrictive, L liberal, Tn troponin, EKG electrocardiogram