Fig. 1.

Reduced microbial diversity in adult survivors of childhood ALL. Rarefaction curves for alpha diversity measured with three different matrices: Chao1, phylogenetic distance and observed OTUs. Microbial diversity was reduced among the survivors as compared to controls (a). Number of observed OTUs, Chao1 index and phylogenetic distance (at the rarefaction of 1000 reads) was reduced in the survivor group as compared to that in controls (b). Data shown as median ± interquartile range and p values was calculated with Student’s t test or Mann-Whitney test. Double dagger denotes non-parametric test was used. OTUs operational taxonomic units