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. Author manuscript; available in PMC: 2017 Mar 21.
Published in final edited form as: Ann Neurol. 2016 Feb 10;79(3):387–403. doi: 10.1002/ana.24573

FIGURE 8.

FIGURE 8

Genetic reduction of Timp3 or vitronectin does not affect the number of granular osmiophilic material (GOM) deposits. Shown are representative electron micrographs of segments of middle cerebral artery from TgN3R169C;Timp3+/+ (A) and TgN3R169C;Timp3+/− mice (B) aged 6 months, and from TgN3R169C;Vtn+/+ (D), TgN3R169C;Vtn+/− (E), and TgN3R169C;Vtn−/−(F) mice aged 12 months. Arrows point to GOM deposits. (C, G) Quantification shows that the number of GOM deposits is comparable between TgN3R169C;Timp3+/+ and TgN3R169C;Timp3+/− mice (C) and between TgN3R169C;Vtn+/+, TgN3R169C; Vtn+/− and TgN3R169C;Vtn−/− mice (G; n = 4 mice per genotype). Significance was determined by Student t test (C) or 1-way analysis of variance followed by Tukey post hoc test (G). Scale bar = 2 μm. ns = nonsignificant.