Figure 4.

Cell-mediated immune response to Ebola virus glycoprotein at days 0, 28, and 42 in volunteers immunized at half and full dose of VSV-glycoprotein and Ad5-glycoprotein. A) Fold increase in interferon-γ production by peripheral blood mononuclear cells exposed to glycoprotein. B) Glycoprotein-specific proliferation of CD4+ T-cells. C) Fold increase in interferon-γ production by peripheral blood mononuclear cells exposed to glycoprotein. Curves show the distribution of individual interferon-γ production in each treatment group at days 0, 28, and 42. D) Glycoprotein-specific proliferation of CD8+ T-cells. *, p < 0.0001.