Table III.
Non-hematologic toxicities regardless of attribution* (Dose Levels 1 and 2)
| CDUS Toxicity Type Code | All Grades (No. of events) | Grade 3 or higher (No. of events) |
|---|---|---|
| Infection | ||
| Febrile neutropenia | 6 | 6 |
| Catheter related infection | 2 | 2 |
| Pneumonia | 4 | 3 |
| Sinusitis | 1 | 1 |
| Skin infection | 2 | 2 |
| Sepsis | 1 | 1 |
| Urinary tract infection | 1 | 1 |
| Gastrointestinal | ||
| Diarrhea | 14 | 4 |
| Vomiting | 7 | 1 |
| Oral hemorrhage | 3 | 1 |
| Cardiovascular | ||
| Hypotension | 3 | 1 |
| Pulmonary | ||
| Dyspnea | 5 | 1 |
| Hypoxia | 4 | 3 |
| Respiratory failure | 1 | 1 |
| Laryngitis | 1 | 1 |
| Nasal congestion | 4 | 2 |
| Stridor | 2 | 2 |
| Neurologic | ||
| Anxiety | 2 | 2 |
| Delirium | 2 | 2 |
| Generalized muscle weakness | 3 | 1 |
| Metabolic | ||
| Acidosis | 1 | 1 |
| Hyperkalemia | 1 | 1 |
| Other | ||
| Fatigue | 12 | 2 |
| Multi-organ failure | 1 | 1 |
*
Clinically insignificant and correctable electrolyte abnormalities are not included in this list.