Table IV.
| Toxicity | All Grades (No. events) | Grade 3 or higher (No. events) |
|---|---|---|
| Infection | ||
| Febrile neutropenia | 26 | 26 |
| Catheter related infection | 10 | 18 |
| C. Difficle Colitis | 2 | 2 |
| Sepsis | 2 | 2 |
| Pneumonia | 8 | 6 |
| Typhlitis | 2 | 2 |
| Gastrointestinal disorders | ||
| Diarrhea | 53 | 8 |
| Renal | ||
| Decreased urine output | 2 | 2 |
| Acute kidney injury | 4 | 3 |
| Dehydration | 3 | 3 |
| Cardiovascular | ||
| Ejection fraction decreased | 1 | 1 |
| Electrocardiogram QT corrected interval prolonged | 13 | 2 |
| Left ventricular systolic dysfunction | 1 | 1 |
| Hypertension | 8 | 6 |
| Hypotension | 16 | 2 |
| Atrial fibrillation | 1 | 1 |
| Edema | 23 | 2 |
| Pulmonary | ||
| Hypoxia | 12 | 5 |
| Respiratory failure | 3 | 3 |
| Atelectasis | 2 | 2 |
| Pulmonary edema | 3 | 2 |
| Neurologic | ||
| Peripheral motor neuropathy | 1 | 1 |
| Peripheral sensory neuropathy | 10 | 3 |
*
Clinically insignificant and correctable electrolyte abnormalities are not included in this list.