Table 2.
HR estimates of CHD and ischemic stroke associated with TG and HDL-C status in the SHS
| CHD |
Ischemic stroke |
|||||||
|---|---|---|---|---|---|---|---|---|
| Noncase | Case | Basic model1 | Full model2 | Noncase | Case | Basic model1 | Full model2 | |
| TG3 | ||||||||
| Normal TG | 1,695 (79) | 459 (21) | Reference | Reference | 2,063 (96) | 91 (4) | Reference | Reference |
| High TG | 734 (69) | 330 (31) | 1.57 (1.36–1.81) | 1.19 (1.00–1.42) | 997 (94) | 67 (6) | 1.64 (1.19–2.25) | 1.28 (0.84–1.94) |
| HDL-C3 | ||||||||
| Normal HDL-C | 1,154 (79) | 313 (21) | Reference | Reference | 1,410 (96) | 57 (4) | Reference | Reference |
| Low HDL-C | 1,275 (73) | 476 (27) | 1.44 (1.24–1.67) | 1.17 (0.99–1.39) | 1,649 (94) | 102 (6) | 1.69 (1.22–2.34) | 1.35 (0.89–2.06) |
| TG-HDL status | ||||||||
| Normal TG-HDL | 940 (80) | 238 (20) | Reference | Reference | 1,131 (96) | 47 (4) | Reference | Reference |
| Normal TG, low HDL | 754 (77) | 221 (23) | 1.27 (1.05–1.53) | 1.08 (0.87–1.33) | 931 (95) | 44 (5) | 1.26 (0.83–1.91) | 0.99 (0.62–1.58) |
| High TG, normal HDL | 213 (74) | 75 (26) | 1.39 (1.06–1.81) | 1.04 (0.76–1.41) | 279 (97) | 9 (3) | 0.85 (0.42–1.74) | 0.57 (0.24–1.38) |
| High TG, low HDL | 520 (67) | 255 (33) | 1.89 (1.58–2.27) | 1.32 (1.06–1.64) | 717 (93) | 58 (7) | 2.20 (1.50–3.25) | 1.46 (0.92–2.33) |
Data are reported as n (%) or HR (95% CI).
1Basic models stratified on SHS centers and included age and sex.
2Full models additionally included BMI, smoking (current, past, ever), estimated LDL-C level, diabetes (yes/no), antihypertensive medications (yes/no), categorical physical activity (MET-h/week in quartile), UACR (continuous), and eGFR-MDRD (continuous).
3High TG: fasting TG ≥150 mg/dL; low HDL-C: HDL-C <40 mg/dL (men) or <50 mg/dL (women).