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. 2017 Jan 9;66(4):981–986. doi: 10.2337/db16-0218

Figure 2.

Figure 2

No effect of chronic hyperglycemia on responses of either direct or indirect alloreactive TCR transgenic adoptively transferred cells. A: Number of direct (4C) and indirect (TCR75) alloreactive T cells in draining PLNs of Akita mice and euglycemic littermates 5 days after local alloimmunization. B: Frequency of proliferating (Ki67+) direct (4C) and indirect (TCR75) cells. C: Geometric mean fluorescence intensity (gMFI) of IFNγ in direct (4C) and indirect (TCR75) cells. Black circles, B6; white squares, Akita. Number of samples with no detectable cells in unchallenged mice indicated adjacent to “n.d.” n = 4 per group from four independent experiments. No significant differences between immunized groups after multiple Student t tests with Bonferroni-Dunn corrections.