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. 2017 Feb 6;39(3):527–538. doi: 10.3892/ijmm.2017.2880

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Isopsoralen (ISO) promotes bone-derived marrow mesenchymal stem cell (BMSC) differentiation into osteoblasts. (A) Molecular structure of ISO. (B) CCK8 assays showed that ISO did not significantly affect cell growth at the concentrations used (0.1-100 µM) following treatment for 2 days. (C–E) Alkaline phosphatase (ALP) staining showed that ISO treatment at concentrations of 5-20 µM increased ALP activity in BMSCs under osteogenic differentiation conditions for 2 weeks. ^*P<0.05, ^**P<0.01 and ^***P<0.001 compared to the group without ISO (Con, control). Columns represent the means ± SD from 9 wells/group (B and E).