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. 2017 Feb 6;39(3):527–538. doi: 10.3892/ijmm.2017.2880

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Isopsoralen (ISO) decreases the rate of bone loss following 2 months of treatment. (A) Hematoxylin and eosin staining indicated that ovariectomy (ovariectomized mice, OVX group) increased the number of adipocytes (AD#), whereas ISO decreased the number of adipocytes (G). (B and C) Micro-CT morphometry of murine distal femora shows that the (D) trabecular thickness (Tb.Th), (E) bone volume/total volume (BV/TV), and (F) trabecular number (Tb.N) values in the OVX group were decreased compared to the sham-operated and OVX plus ISO groups. These three indicators were significantly improved by ISO treatment compared to OVX mice. Compared to sham-operated (Sham) group the (D) Tb.Th, (E) BV/TV and (F) Tb.N levels in the OVX + ISO group were also decreased. ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. OVX; ⁺P<0.05 vs. OVX + ISO. Columns represent the means ± SD from 6 mice/group (D–G).